We use Debian in the conduct of day to day business, for bookkeeping with GnuCash, presentations with Open Office, and conducting on-line research with Iceweasel. We use many of the Debian apps used for the display and manipulation of PDF documents such as Evince, PDF Shuffler, PDFSam, pdftk, tesseract, and hocr2pdf.
For image manipulation we use GThumb, The GIMP, and Open Office Draw. For video work we use mencoder, Parole, and VLC, among other tools.
We currently have a desktop computer and two laptop computers that are loaded with Debian Squeeze/Wheezy. We chose Debian because we find it to be more flexible than Windows for meeting our needs. We also value Debian's stability.